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Clinical reports on Lingzhi's efficacy for hypertension treatment
2016-06-05   Source:    Hit:553   Font: 
In the 1970s, physicians in China found that Lingzhi decoction and the liquid fermentation medium of the cultured Lingzhi mycelium could lower the blood pressure of and improve the symptoms on hypertension patients. Later on, Japanese researchers, Kanmatsuse and his colleagues, reported in 1985 their experiment with 53 participating hypertension patients. The patients were divided into two groups: Group A had been diagnosed with essential hypertension according to World Health Organization(WHO)criteria, and Group B were either normal or slightly high on their blood pressure readings. Six Lingzhi tablets(i.e., 240mg freeze-dried G.lucidum extract/tablet)per day were administered to each person for 6 months. The results showed that the blood pressure of the patients in Group A lowered significantly. Ten percent of the patients had their systolic blood pressure decreased 20-29 mmHg and 47.5% decreased 10-19 mmHg. On the diastolic blood pressure, 17.5% of the patients decreased 10-14 mmHg and 41.5% patients decreased 5-9 mmHg. The average blood pressures were reduced from 156.6/103.5 mmHg to 136.6/92.8 mmHg with the 6 months therapy. Moreover, patients’ serum total cholesterol and LDL levels were also lowered. On the other hand , no obvious changes on the blood pressures were found in Group B. Kanmatsuse, K, et al. Studies on Ganoderma Lucidum I. efficacy against hypertension and side effects. Yakugago Zasshi,1985,105(10): 942-947. A double-blind placebo-controlled clinical study conducted by Zhang et al(1999) showed a significant synergy between Lingzhi and the conventional anti-hypertension drugs in treating patients. All 40 patients had been diagnosed with essential hypertension according to WHO criteria. The patients were given three times a day 25 mg of the angiotensin-converting enzyme inhibitor, Captopril, or 20 mg of the calcium channel blockers, Nimodipine. After no less than one month of ineffective treatment, the patients were administered a dosage of Lingzhi and the drug. The Lingzhi tablets were freeze-dried extract of G.lucidum. Each tablet contained 55 mg G.lucidum. extract, equivalent to 1.375 g of the fruiting body. A placebo was used that contained no Lingzhi. Two Lingzhi or placebo tablets were given to the patients along with the prescription drug. Among 40 patients, whose average blood pressures were higher than 140/90 mmHg, 27 were given the combination therapy and 13 on placebo. In two weeks, a significant decrease on average blood pressure was observed in the group treated with Lingzhi in combination with the drug. And after three months, all patients in that group had their blood pressures dropped to 140/90 mmHg or below. Meanwhile, the aortic and capillary pressures were also decreased significantly, and the microcirculation of nail wall was considerably improved. For patients treated with placebo, no significant changes on those indices were found. This synergetic effect between Lingzhi and anti-hypertension drugs might be the result of the improved blood circulation due to the increased density and diameter of capillary blood vessels, as well as red cell flow rate. In addition, blood glucose levels decreased significantly from 5.81+-1.67mmol/L to 4.73+-0.98 mmol/L (P<0.05)after3 months therapy. But there were little differences in serum total cholesterol, triglycerides and HDL levels between the two groups. In further studies, it was found that the plasma viscosity was also reduced in patients receiving the combination therapy of Lingzhi slices and the drug.The reduced blood rheological characteristics included viscosities at low and high shear rates, plasma viscosity, hematocrit values and erythrocyte sedimentation rate (Table 6-3).At the same time, the blood glucose lowered significantly and the plasma nitric oxide(NO) increased markedly in the patients administered with the combination therapy. The regression analysis showed a positive correlation between elevated NO and decreased capillary pressure. The result suggest that long-term anti-hypertension drugs combined with Lingzhi can be solution for serious hypertension patients. Lingzhi induced serum NO increase might be one of the factors that causes the improvement in microcirculation. Zhang, K.P.et al. Effect of Ganoderma Lucidum combined with hypotensor on blood sugar, plasma NO, microcirculation and hemor-rheology in treatment refractory hypertension. J. China Microcirulation,1999,3(2):75-78 Therefore, Lingzhi is effective in treating hypertension, especially when it is combined with conventional anti-hypertension drugs. In addition, Lingzhi preparations could improve subjective symptoms in hypertension patients.
      
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