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GL-PS protect fibroblasts against UVB-induced photoaging
2021-10-12    Hit:16   Font: 
January 2017 / The Third Xiangya Hospital of Central South University / Molecular Medicine Reports

Text/ Wu Tingyao
Ultraviolet rays in the sun are a heavyweight killer of skin aging because it increases the concentration of reactive oxygen species (ROS) in the skin, destroys collagen, and makes the skin appear sagging and wrinkles. This is the so-called "photoaging".

According to the research results published by the Third Xiangya Hospital of Central South University in Hunan in "Molecular Medicine Reports" in January 2017, Ganoderma lucidum polysaccharides (GL-PS), which has always been known for regulating immunity, suppressing tumors and fighting free radicals, may also be able to resist skin photoaging caused by the sun.

Researchers directly obtained fibroblasts from human skin, cultured them in vitro, allowed the cells to proliferate, and then irradiated them with ultraviolet B (UVB) to establish an experimental cell model of photoaging. Fibroblasts located in the dermis are the source of collagen and elastic fibers. Therefore, the condition of the cells and their secreted substances can reflect the severity of photoaging.

It was found that under ultraviolet irradiation, the viability of human skin fibroblasts decreased (Figure 1), their aging increased, and type 1 collagen decreased (there are three types of collagen in human skin. More than 80% of them are type 1), the concentration of the enzyme MMP-1 (type 1 matrix metalloproteinase) that can decompose collagen increased, and the level of reactive oxide species (ROS) also rose sharply.

In contrast, for human skin fibroblasts pre-cultured with Ganoderma lucidum polysaccharides (concentration 10, 20 or 40 µg/mL), the reactive oxide species triggered by ultraviolet rays significantly reduced, and the indicators related to skin aging significantly weakened (Figure 2-6).
Figure 1 Ultraviolet rays can kill and wound human skin fibroblasts
Under the same irradiation time (48 hours), the stronger the UVB radiation dose, the smaller the number of fibroblasts responsible for the production of collagen.
Figure 2 Ganoderma lucidum polysaccharides can reduce the lethality of ultraviolet rays on fibroblasts

Also, after being irradiated with UVB for 24 hours, the viability of human skin fibroblasts cultured with Ganoderma lucidum polysaccharides (GL-PS) was significantly higher than that of cells without GL-PS protection and even higher than that of the control group (neither cultured with GL-PS nor exposed to ultraviolet ray).
Figure 3 Ganoderma lucidum polysaccharides can reduce cell aging caused by ultraviolet rays

Similarly, after 24 hours of UVB irradiation, the aging number of human skin fibroblasts cultured with Ganoderma lucidum polysaccharides (GL-PS) is significantly less than that of the fibroblasts without GL-PS protection.
Figure 4 Ganoderma lucidum polysaccharides can inhibit the induction of MMP-1 by ultraviolet ray

MMP-1 can decompose collagen, and its concentration will continue to increase with UVB irradiation (24 hours), but Ganoderma lucidum polysaccharides (GL-PS) can alleviate this situation and even make the concentration of MMP-1 close to that of the control group (which is neither cultivated with GL-PS nor irradiated with ultraviolet rays).

Figure 5 Ganoderma lucidum polysaccharides can reduce the damage of ultraviolet rays to collagen

Collagen is an important element for maintaining the skin youthfulness. Its concentration will be reduced by UVB irradiation (24 hours), but Ganoderma lucidum polysaccharides (GL-PS) can improve this condition and even maintain the concentration of collagen at the level of the control group ( Neither cultivated with GL-PS nor irradiated with UVB).

Figure 6 Ganoderma lucidum polysaccharides can inhibit the generation of UVB-induced reactive oxygen species
The reason why ultraviolet rays cause skin aging is closely related to the increase of reactive oxygen species. Ganoderma lucidum polysaccharides (GL-PS) can reduce the generation of free radicals, and the effect is proportional to the dose of GL-PS.

This research has shown us the ability of Ganoderma lucidum polysaccharides to resist UVB damage and reduce photo-aging. This is the result of the direct interaction between Ganoderma lucidum polysaccharides and human skin fibroblasts. As long as the Ganoderma lucidum polysaccharides can be transported from the epidermis to the dermis to interact with fibroblasts, GL-PS may be able to help us resist the aging process caused by the sun and keep the skin young.

[Source] Zeng Q, et al. Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. Mol Med Rep. 2017 Jan;15(1):111-116.
About the author/ Ms. Wu Tingyao
Wu Tingyao has been reporting on first-hand Ganoderma information since 1999. She is the author of Healing with Ganoderma (published in The People's Medical Publishing House in April 2017). 
★ This article is published under the exclusive authorization of the author. ★ The above works cannot be reproduced, excerpted or used in other ways without the authorization of the author. ★ For violations of the above statement, the author will pursue relevant legal responsibilities. ★ The original text of this article was written in Chinese by Wu Tingyao and translated into English by Alfred Liu. If there is any discrepancy between the translation (English) and the original (Chinese), the original Chinese shall prevail. If readers have any questions, please contact the original author, Ms. Wu Tingyao.
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